As a successful entrepreneur focused on technological breakthroughs, Jason Hope maintains an active role in keeping up with those breakthroughs as well as using them to found promising businesses and to benefit human life in general. He grew up in Tempe Arizona and went to school at Arizona State University, where he earned both his undergraduate B.S. degree in Finance and his Masters of Business Administration from the W.P. Carey School of Business.
Jason Hope’s two big passions are the Internet of Things and using biotechnology to extend human life indefinitely. He has donated $500,000 to the SENS Research Foundation to help them discover the medical breakthroughs that will heal and reverse all damage caused by aging at the cellular level.
In an article he published online, Hope describes how SENS is addressing one form of cellular damage that adversely affects human health: senescent cells. These are cells which have a programming in place to keep them from growing in an uncontrolled way, which is basically cancer. However, senescent cells do their own form of damage to our health because they produce substances that are inflammatory. If there are only a few of them, this is not a problem. However, as we age, we have more senescent cells.
Their programming keeps them from growing and dividing into new cells. That is good, because continuing growth could develop into cancer. In the skin, uncontrolled growth would mean the formation of extra scar tissue to heal a wound. Over time, as people age, they develop many of these senescent cells, and their secretions damage the normal tissue cells surrounding them. The two possible solutions to rid the body of these senescent cells is to develop some kind of drug that kills senescent cells while leaving normal, healthy cells unharmed. The other possibility is to enhance the immune system so it kills and removes the senescent cells. Killing these senescent cells would help prevent disease by making room for new, young and healthy cells.
Senescent cells should be easy to target. They have abnormal surface markers that healthy cells do not have. At the University of Arizona, using a grant from SENS, scientists are studying ways to enhance the immune systems of healthy mice by purging them of unhealthy anergic T-cells from their elderly immune systems. This could improve the effectiveness of their immune systems by allowing them to produce healthy new immune cells.
Jason Hope’s Facebook Page: www.facebook.com/jason.r.hope